Reference type

Journal Article
 

Record Number

31

Author

Kim, S.J.; Spradbrow, P.B.

Year

1978

Title

Administration of a vaccine prepared from the Australian V4 strain of Newcastle disease virus by aerosol and drinking water

Journal

Australian Veterinary Journal

Volume

54

Pages

486-489

Label

Journal

Keywords

Aerosol vaccine, Australia, Drinking water vaccine, V4 vaccine

Notes

An experimental vaccine containing the avirulent Australian V4 strain of Newcastle disease virus was used to vaccinate 3- or 6-week-old chickens by aerosol and drinking water application. The chickens lacked maternally derived antibody to Newcastle disease virus.
When the vaccine virus was diluted in tap water more than 90% of the infectivity was destroyed immediately. The addition of 0.25% skim milk prevented this loss and there was no loss in distilled water. Rates of inactivation at 37oC were similar in tap water and distilled water and were unaffected by the addition of skim milk.

Both methods of vaccination resulted in the production of haemagglutination-inhibition antibodies which persisted for at least 8 to 12 weeks. The antibody response to aerosol vaccination was significantly better than that following drinking water vaccination. No clinical disease was induced by exposure to vaccine virus.