Reference type

Journal Article
 

Record Number

36

Author

Schalkoort, R.; Spradbrow, P.B.

Year

1980

Title

Aerosol vaccination of chickens with the V4 strain of Newcastle disease virus

Journal

Australian Veterinary Journal

Volume

56

Pages

429-433

Label

Journal

Keywords

Aerosol vaccine, Australia, V4 vaccine

Notes

Two-week-old chickens, free of detectable maternal antibody to Newcastle disease virus (NDV), or with low levels of maternal antibody, were vaccinated with the V4 strain of NDV. Haemagglutination inhibition (HI) antibodies were determined at intervals after vaccination.
Two hundred chickens were vaccinated by exposure to an aerosol, a dose of 106 50% embryo infectious doses (EID50) being allowed per chicken. Forty unvaccinated chickens were placed in direct contact with vaccinated chickens. Most of the vaccinated chickens and the in-contact chickens had developed HI antibodies of titre 2³ (8) within 2 weeks of vaccination. The HI antibodies in many chickens persisted for at least 8 weeks. Control chickens in a shed 15 metres from the shed containing the vaccinated chickens did not develop HI antibodies to NDV. NDV could be isolated from some vaccinated chickens for 15 days after vaccination.

An aerosol dose of 105 EID50 per chicken failed to induce a serological response in 2 groups of 40 chickens each. HI antibodies were produced in 1 of 2 groups, each of 40 chickens, vaccinated with 106 EID50 and in both of 2 groups of 40 chickens each vaccinated with 107 EID50.